Potassium Hydroxide → Hydrochloric Acid

Participants

Reaction Steps

The operation is as in Example 14, but starting from 6 g of 1-[2-(4-chloro-phenyl)-4-quinolyl]-2-(4-piperidyl)ethanone, prepared as indicated in Example 7, 2.5 g of 98% hydrazine hydrate and 2.73 g of potassium hydroxide in 25 ml of diethylene glycol. 2.1 g are obtained of 2-(4-chloro-phenyl)-4-[2-(4-piperidyl)-ethyl]-quinoline in the form of monohydrochloride, which melts above 260° C.

Provenance & Evidence