Potassium Hydroxide → Hydrochloric Acid

HRID 1388794Notes

Reaction equation

HRID 1388794 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:17]=[C:16]([C:18](=O)[CH2:19][CH:20]3[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]3)[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[N:9]=2)=[CH:4][CH:3]=1.O.NN.[OH-].[K+]>C(O)COCCO>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:17]=[C:16]([CH2:18][CH2:19][CH:20]3[CH2:21][CH2:22][NH:23][CH2:24][CH2:25]3)[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[N:9]=2)=[CH:4][CH:3]=1.[ClH:1]

Participants

6

Reactant 3

HCID 14797Potassium HydroxideHCID 24654Hydrazine hydrate (1:1)HCID 3062070HCID 3062070, compound

Product 2

HCID 313Hydrochloric AcidHCID 3062088HCID 3062088, compound

Reagents, catalysts & solvents 1

HCID 8117Diethylene GlycolSolvent

Procedure

The operation is as in Example 14, but starting from 6 g of 1-[2-(4-chloro-phenyl)-4-quinolyl]-2-(4-piperidyl)ethanone, prepared as indicated in Example 7, 2.5 g of 98% hydrazine hydrate and 2.73 g of potassium hydroxide in 25 ml of diethylene glycol. 2.1 g are obtained of 2-(4-chloro-phenyl)-4-[2-(4-piperidyl)-ethyl]-quinoline in the form of monohydrochloride, which melts above 260° C.

Workup

  1. customprepared

Sources & evidence

ORD record
ord-bdfab8153f5942a9854c863591132692
Source dataset
uspto-grants-1984_02
Patent number
US04433150

Reaction notes

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