反应详情

2.18 g (4.1 mmol) of Nε -benzyloxycarbonyl-lysyl-prolyl-arginine IV in 30 ml of water are added, under stirring, to a solution of 2.10 g (5.3 mmol) of pentafluorophenyl ether of tert.butyloxycarbonyl-threonine in 70 ml of dioxane. Then the reaction mixture is treated following the procedure described for the synthesis of compound III. The yield of the desired product--tert.butyloxycarbonyl-threonyl-Nε -benzyloxycarbonyl-lysyl-prolyl-arginine is 2.65 g (188%).

1. additionThen the reaction mixture is treated