HCID 12553985, compound → 4-Methoxypyrimidin-5-amine

HRID 1388894Notes

Reaction equation

HRID 1388894 reaction equation
[CH3:1][O:2][C:3]1[C:8]([N+:9]([O-])=O)=[CH:7][N:6]=[CH:5][N:4]=1>CO.[Ni]>[NH2:9][C:8]1[C:3]([O:2][CH3:1])=[N:4][CH:5]=[N:6][CH:7]=1

Participants

4

Reactant 1

HCID 12553985HCID 12553985, compound

Product 1

HCID 132774654-Methoxypyrimidin-5-amineYield 99.2%

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 887MethanolSolvent

Procedure

10 g 4-methoxy-5-nitropyrimidine in 500 ml methanol are hydrated for 2.5 hours at 2 bar in the presence of 4.5 g Raney nickel. After filtration, the solution is concentrated. 8.0 g 5-amino-4-methoxypyrimidine having a melting point of 71° to 74° C. are obtained.

Workup

  1. filtrationAfter filtration
  2. concentrationthe solution is concentrated

Sources & evidence

ORD record
ord-58999e9308004d959a9a6d7a0a7620e1
Source dataset
uspto-grants-1984_02
Patent number
US04434167

Reaction notes

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