Sodium Hydroxide → HCID 13345723, compound

HRID 1388933Notes

Reaction equation

HRID 1388933 reaction equation
[CH3:1][N:2]1[C:6]([C:7]([C:9]2[N:10]([CH3:15])[C:11]([Cl:14])=[CH:12][CH:13]=2)=[O:8])=[C:5]([CH3:16])[CH:4]=[C:3]1[CH2:17][C:18]([O:20]CC)=[O:19].[OH-].[Na+]>>[CH3:1][N:2]1[C:6]([C:7]([C:9]2[N:10]([CH3:15])[C:11]([Cl:14])=[CH:12][CH:13]=2)=[O:8])=[C:5]([CH3:16])[CH:4]=[C:3]1[CH2:17][C:18]([OH:20])=[O:19]

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 20469133HCID 20469133, compound

Product 1

HCID 13345723HCID 13345723, compoundYield 90%

Procedure

Seven grams of ethyl 1,4-dimethyl-5-(1-methyl-5'-chloropyrrol-2-oyl)pyrrole-2-acetate (0.23 mole) is hydrolyzed with 25 ml 10% NaOH solution at room temperature. After acidifying and extracting with methylene chloride, the crude product is crystallized upon removal of solvent to give 6.1 g (90%) of crystalline 1,4-dimethyl-5-(1-methyl-5'-chloropyrrol-2-oyl)pyrrole-2-acetic acid, m.p. 148°-149° C.

Workup

  1. extractionextracting with methylene chloride
  2. customthe crude product is crystallized upon removal of solvent

Sources & evidence

ORD record
ord-a6ac43db8afd4f8986f1ea6bca574391
Source dataset
uspto-grants-1984_02
Patent number
US04434175

Reaction notes

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