HCID 20469085, compound → HCID 20469104, compound

HRID 1388936Notes

Reaction equation

HRID 1388936 reaction equation
[CH3:1][N:2]1[C:6]([C:7]([C:9]2[N:10]([CH3:18])[C:11]([C:14]([F:17])([F:16])[F:15])=[CH:12][CH:13]=2)=[O:8])=[C:5]([CH3:19])[C:4](C(O)=O)=[C:3]1[CH2:23][C:24]([OH:26])=[O:25]>FC(F)(F)C(O)=O>[CH3:1][N:2]1[C:6]([C:7]([C:9]2[N:10]([CH3:18])[C:11]([C:14]([F:15])([F:16])[F:17])=[CH:12][CH:13]=2)=[O:8])=[C:5]([CH3:19])[CH:4]=[C:3]1[CH2:23][C:24]([OH:26])=[O:25]

Participants

3

Reactant 1

HCID 20469085HCID 20469085, compound

Product 1

HCID 20469104HCID 20469104, compoundYield 67%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

A mixture of 1.87 g (5 mmole) of 1,4-dimethyl-3-hydroxycarbonyl-5-(1-methyl-5-trifluoromethylpyrrol-2-oyl)pyrrole-2-acetic acid is heated together with 10 ml trifluoroacetic acid at 80° C. for thirty minutes. TFA is removed in vacuo. The residue is crystallized from ethyl acetate/hexane. After drying, 1.1 g of 1,4-dimethyl-5-(1-methyl-5-trifluoromethylpyrrol-2-oyl)pyrrole-2-acetic acid is obtained.

Workup

  1. customTFA is removed in vacuo
  2. customThe residue is crystallized from ethyl acetate/hexane
  3. customAfter drying

Sources & evidence

ORD record
ord-bf0407d6734d495e804e5facab41dc97
Source dataset
uspto-grants-1984_02
Patent number
US04434175

Reaction notes

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