Hydrochloric Acid → HCID 178446029, compound

HRID 1388964Notes

Reaction equation

HRID 1388964 reaction equation
[NH:1](C(OC(C)(C)C)=O)[C@@H:2]([C:7]([N:9]1[CH2:34][CH2:33][CH2:32][C@H:10]1[C:11]([NH:13][C@H:14]([C:22]([S:24][CH2:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)=[O:23])[CH2:15][CH2:16][CH2:17][NH:18][C:19](=[NH:21])[NH2:20])=[O:12])=[O:8])[CH2:3][CH:4]([CH3:6])[CH3:5].[ClH:42]>>[NH2:1][C@@H:2]([C:7]([N:9]1[CH2:34][CH2:33][CH2:32][C@H:10]1[C:11]([NH:13][C@H:14]([C:22]([S:24][CH2:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)=[O:23])[CH2:15][CH2:16][CH2:17][NH:18][C:19](=[NH:20])[NH2:21])=[O:12])=[O:8])[CH2:3][CH:4]([CH3:5])[CH3:6].[ClH:42].[ClH:42]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 178446048HCID 178446048, compound

Product 1

HCID 178446029HCID 178446029, compound

Procedure

Boc-D-Leu-Pro-Arg-S-Bzl (0.845 g), prepared in Step E above, is mixed with HCl for approximately 30 minutes to remove the Boc protecting group. The product is precipitated with ether to give 0.713 g of pure H-D-Leu-Pro-Arg-S-Bzl.2HCl.

Workup

  1. customto remove the Boc protecting group
  2. customThe product is precipitated with ether

Sources & evidence

ORD record
ord-cad53f5795a242fe8c5ed857a907af33
Source dataset
uspto-grants-1984_02
Patent number
US04434096

Reaction notes

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