反应详情

The procedure of Example 12 was employed utilizing ethyl-2-(4'-trifluoromethylbenzoyl)-3-dimethylaminopropenoate in lieu of ethyl-2-(2',4'-dichlorobenzoyl)-3-dimethylaminopropenoate to yield ethyl-5-(4'-trifluoromethylphenyl)-4-isoxazolecarboxylate (2.03 g.; 47% yield) as yellow crystals having a melting point of 42°-44° C. and the following analysis: