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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1389005Generated: October 26, 2026

HCID 54095551, compound → Ethyl 5-(4-trifluoromethylphenyl)isoxazole-4-carboxylate

https://huagongshe.com/reaction/1389005

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHCID 54095551HCID 54095551—
ReactantEthyl 3-dimethylamino-2-(4-trifluoromethyl-benzoyl)-acrylateHCID 54156258—
ProductEthyl 5-(4-trifluoromethylphenyl)isoxazole-4-carboxylateHCID 2222137447%

Reaction Steps

The procedure of Example 12 was employed utilizing ethyl-2-(4'-trifluoromethylbenzoyl)-3-dimethylaminopropenoate in lieu of ethyl-2-(2',4'-dichlorobenzoyl)-3-dimethylaminopropenoate to yield ethyl-5-(4'-trifluoromethylphenyl)-4-isoxazolecarboxylate (2.03 g.; 47% yield) as yellow crystals having a melting point of 42°-44° C. and the following analysis:

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04243406
Source datasetuspto-grants-1981_01
ORD IDord-381ab027cddc4f19a00c01c9d831e519
Source noteuspto-grants-1981_01