HCID 54255784, compound → Ethyl 5-(3-chlorophenyl)isoxazole-4-carboxylate

HRID 1389009Notes

Reaction equation

HRID 1389009 reaction equation
[CH2:1]([O:3][C:4](=[O:19])[C:5]([C:10](=[O:18])[C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([Cl:17])[CH:12]=1)=[CH:6][N:7](C)C)[CH3:2].C(OC(=O)C(C(=O)C1C=CC=CC=1)=CN(C)C)C>>[CH2:1]([O:3][C:4]([C:5]1[CH:6]=[N:7][O:18][C:10]=1[C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([Cl:17])[CH:12]=1)=[O:19])[CH3:2]

Participants

3

Reactant 2

HCID 54255784HCID 54255784, compoundHCID 54499154Ethyl-2-benzoyl-3-dimethylaminopropenoate

Product 1

HCID 22221485Ethyl 5-(3-chlorophenyl)isoxazole-4-carboxylateYield 51%

Procedure

The procedure of Example 15 was employed utilizing ethyl-2-(3'-chlorobenzoyl)-3-dimethylaminopropenoate in lieu of ethyl-2-benzoyl-3-dimethylaminopropenoate to yield ethyl-5-(3'-chlorophenyl)-4-isoxazolecarboxylate (3.2 g.; 51% yield) having a melting point of 75°-77° C. and the following analysis:

Sources & evidence

ORD record
ord-2f23c084072246279a3b9f9994bdf5be
Source dataset
uspto-grants-1981_01
Patent number
US04243406

Reaction notes

Loading…