HCID 53723120, compound → HCID 20297496, compound

HRID 1389012Notes

Reaction equation

HRID 1389012 reaction equation
[CH2:1]([O:3][C:4](=[O:19])[C:5]([C:10](=[O:18])[C:11]1[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=1)=[CH:6][N:7](C)C)[CH3:2].C(OC(=O)C(C(=O)C1C=CC(Cl)=C(Cl)C=1)=CN(C)C)C>CCCCC>[CH2:1]([O:3][C:4]([C:5]1[CH:6]=[N:7][O:18][C:10]=1[C:11]1[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=1)=[O:19])[CH3:2]

Participants

4

Reactant 2

HCID 53723120HCID 53723120, compoundHCID 54489964HCID 54489964, compound

Product 1

HCID 20297496HCID 20297496, compoundYield 74.5%

Reagents, catalysts & solvents 1

HCID 8003PentaneSolvent

Procedure

The procedure of Example 20 was employed utilizing ethyl-2-(4'-fluorobenzoyl)-3-dimethylaminopropenoate in lieu of ethyl-2-(3',4'-dichlorobenzoyl)-3-dimethylaminopropenoate to yield upon recrystallization with pentane, ethyl-5-(4'-fluorophenyl)-4-isoxazolecarboxylate (1.75 g.; 74.5% yield) as a white solid having a melting point of 34°-38° C. and the following analysis:

Sources & evidence

ORD record
ord-009342b1fc5540e496d1ba931a0469aa
Source dataset
uspto-grants-1981_01
Patent number
US04243406

Reaction notes

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