反应详情

温度

150 °C

A mixture of 4.0 g of ethyl 4-amino-3-fluorobenzoate, 6.66 g of hexadecyl bromide and 3.0 g of potassium carbonate in 25 ml of hexamethyl phosphoramide is stirred at 150° C. for 20 hr. The mixture is cooled, diluted with water and extracted with ether. The ether extract is washed with water, dried, and the ether evaporated. The residue is recrystallized from hexane to yield ethyl 3-fluoro-4-(hexadecylamino)benzoate as a white solid.

1. temperatureThe mixture is cooled
2. extractionextracted with ether
3. extractionThe ether extract
4. washis washed with water
5. customdried
6. customthe ether evaporated
7. customThe residue is recrystallized from hexane