HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Ethyl 3-fluoro-4-(hexadecylamino)benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Borane | HCID 6331 | — |
| Reactant | Ethyl 3-fluoro-4-(hexadecanoylamino)benzoate | HCID 20536492 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Ethyl 3-fluoro-4-(hexadecylamino)benzoate | HCID 20536470 | — |
Reaction Steps
A solution of 5 g of ethyl 3-fluoro-4-(hexadecanoylamino)benzoate in 50 ml of tetrahydrofuran is slowly added with stirring to 13 ml of 1 M borane in tetrahydrofuran. The resulting solution is then poured into 50 ml of 10% aqueous hydrochloric acid and the resulting mixture is filtered. The residue is crystallized from acetonitrile to yield ethyl 3-fluoro-4-(hexadecylamino)benzoate as white crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04243609 |
| Source dataset | uspto-grants-1981_01 |
| ORD ID | ord-b3195ad09bd54867a17a8a6dd8d6722d |
| Source note | uspto-grants-1981_01 |