Hydrochloric Acid → HCID 20298226, compound

HRID 1389125Notes

Reaction equation

HRID 1389125 reaction equation
C([O:3][C:4](=[O:16])[C:5]([C:7]1[NH:8][C:9]([S:12][CH2:13][CH2:14][CH3:15])=[CH:10][CH:11]=1)=[O:6])C.[OH-].[Na+].Cl>O>[CH2:13]([S:12][C:9]1[NH:8][C:7]([C:5](=[O:6])[C:4]([OH:16])=[O:3])=[CH:11][CH:10]=1)[CH2:14][CH3:15]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 53670101HCID 53670101, compound

Product 1

HCID 20298226HCID 20298226, compoundYield 33%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 5-n-propylthio-2-pyrrolylglyoxylic acid ethyl ester (2.4 g.) and sodium hydroxide (1.0 g.) in water (100 ml.) was heated on a steam bath for 3 hours. The solution was cooled, acidified to pH 1 with dilute hydrochloric acid and the product extracted with chloroform. Evaporation of the solvent and recrystallization from petroleum ether (B.P. 40°-60°) gave 5-n-propylthio-2-pyrrolylglyoxylic acid (0.7 g.) as yellow crystals, M.P. 87°. Found: C, 50.34; H, 5.21; N, 6.54. C9H11NO3S requires: C, 50.68; H, 5.20; N, 6.57%.

Workup

  1. temperaturewas heated on a steam bath for 3 hours
  2. temperatureThe solution was cooled
  3. extractionthe product extracted with chloroform
  4. customEvaporation of the solvent and recrystallization from petroleum ether (B.P. 40°-60°)

Sources & evidence

ORD record
ord-3697d3a522074b2d803f8b098d3e5694
Source dataset
uspto-grants-1981_01
Patent number
US04243672

Reaction notes

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