Epichlorohydrin → HCID 20298520, compound

HRID 1389170Notes

Reaction equation

[CH2:1]([CH:3]1[O:5][CH2:4]1)[Cl:2].[CH:6]([S:9][C:10]1[CH:15]=[CH:14][C:13]([OH:16])=[CH:12][CH:11]=1)([CH3:8])[CH3:7].[CH:17]1([CH2:23][CH2:24][NH2:25])[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1>>[ClH:2].[CH:17]1([CH2:23][CH2:24][NH:25][CH2:1][CH:3]([OH:5])[CH2:4][O:16][C:13]2[CH:14]=[CH:15][C:10]([S:9][CH:6]([CH3:8])[CH3:7])=[CH:11][CH:12]=2)[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1

Participants

Reactant 3

HCID 7835Epichlorohydrin

HCID 205092-Cyclohexylethylamine

HCID 130584534-(Propan-2-ylsulfanyl)phenol

Product 1

HCID 20298520HCID 20298520, compoundYield 18%

Procedure

Reaction of the epichlorohydrin derivative of 4-(isopropylthio)phenol (5.0 g., 0.022 mole) with cyclohexylethylamine (3.3 g., 0.026 mole) according to the procedure of Example 2(b) and crystallization of the crude product from isopropyl alcohol affords an 18% yield of analytically pure 1-[(2-cyclohexylethyl)amino]-3-[4-[(1-methylethyl)thio]phenoxy]-2-propanol hydrochloride, m.p. 180°-182° (corr.).

Workup

customaccording to the procedure of Example 2(b) and crystallization of the crude product from isopropyl alcohol

Sources & evidence

ORD record: ord-f51a32b033d74ebcb3cf616567827ee1
Source dataset: uspto-grants-1981_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04243681

Reaction notes

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