Epichlorohydrin → HCID 20298496, compound

HRID 1389171Notes

Reaction equation

HRID 1389171 reaction equation
[CH2:1]([CH:3]1[O:5][CH2:4]1)[Cl:2].[CH:6]([S:9][C:10]1[CH:15]=[CH:14][C:13]([OH:16])=[CH:12][CH:11]=1)([CH3:8])[CH3:7].[CH:17]1([CH2:23][CH2:24][CH2:25][CH2:26][NH2:27])[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1>>[ClH:2].[CH:17]1([CH2:23][CH2:24][CH2:25][CH2:26][NH:27][CH2:1][CH:3]([OH:5])[CH2:4][O:16][C:13]2[CH:14]=[CH:15][C:10]([S:9][CH:6]([CH3:8])[CH3:7])=[CH:11][CH:12]=2)[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1

Participants

4

Reactant 3

HCID 7835EpichlorohydrinHCID 30589564-cyclohexylbutan-1-amineHCID 130584534-(Propan-2-ylsulfanyl)phenol

Product 1

HCID 20298496HCID 20298496, compoundYield 11.4%

Procedure

Reaction of the epichlorohydrin derivative of 4-(isopropylthio)phenol (9.0 g., 0.04 mole) with cyclohexylbutylamine (6.7 g., 0.043 mole) according to procedure of Example 2(b) and crystallization of the crude product from ethanol affords an 11.4% yield of analytically pure 1-[(4-cyclohexylbutyl)amino]-3-[4-[(1-methylethyl)thio]phenoxy]-2-propanol hydrochloride, m.p. 179° with prior softening from 118°.

Workup

  1. customaccording to procedure of Example 2(b) and crystallization of the crude product from ethanol

Sources & evidence

ORD record
ord-f2f3998489404d2da312a5792d4e00b2
Source dataset
uspto-grants-1981_01
Patent number
US04243681

Reaction notes

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