2-Aminobiphenyl → HCID 20298423, compound

HRID 1389219Notes

Reaction equation

HRID 1389219 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.C(N(C(C)C)C(C)C)C.Br[CH2:24][CH2:25][CH2:26][CH2:27][C:28]([O:30][CH2:31][CH3:32])=[O:29]>>[C:3]1([C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=2)[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[NH:1][CH2:24][CH2:25][CH2:26][CH2:27][C:28]([O:30][CH2:31][CH3:32])=[O:29]

Participants

4

Reactant 3

HCID 70152-AminobiphenylHCID 81531DiisopropylethylamineHCID 84580Ethyl 5-bromovalerate

Product 1

HCID 20298423HCID 20298423, compoundYield 91%

Procedure

50.0 g of 2-aminobiphenyl, 38.2 g of ethyldiisopropylamine and 61.9 g of ethyl 5-bromovalerate are reacted analogously to Example 47a) to obtain 80.0 g of ethyl 5-(biphenyl-2-yl)aminovalerate as a non-crystallizing oil.

Sources & evidence

ORD record
ord-9cbbd65f986c460b9538699d127a2460
Source dataset
uspto-grants-1981_01
Patent number
US04243678

Reaction notes

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