HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloroform → 3-Fluoro-10-[4-(3-hydroxypropyl)piperazino]-8-isopropyl-10,11-dihydrodibenzo (b,f) thiepin
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloroform | HCID 6212 | — |
| Reactant | Piperazin-1-ylpropanol | HCID 79207 | — |
| Reactant | 3-Fluoro-8-isopropyl-10-(4-methylpiperazino)-10,11-dihydrodibenzo(b,f)thiepin | HCID 3054166 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3-Fluoro-10-[4-(3-hydroxypropyl)piperazino]-8-isopropyl-10,11-dihydrodibenzo (b,f) thiepin | HCID 13076174 | — |
Reaction Steps
A mixture of 4.0 g 10-chloro-3-fluoro-8-isopropyl-10,11-dihydrodibenzo (b,f) thiepin (Example 1), 4.0 g 1-(3-hydroxypropyl) piperazine (T. Zawisa et al., Acta Polon. Pharm. 22, 477, 1965) and 7 ml of chloroform was refluxed for 5 hours and then processed in the manner described in Example 2. 4.4 g (76%) of an oily base which was converted to a crystalline dimaleate, m.p. 106°-108° C. (ethanol) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04243805 |
| Source dataset | uspto-grants-1981_01 |
| ORD ID | ord-4918a5b5d2d146c69c34c3f844966515 |
| Source note | uspto-grants-1981_01 |