Hydrochloric Acid → HCID 20298830, compound

HRID 1389309Notes

Reaction equation

HRID 1389309 reaction equation
[OH-].[Na+].[C:3]1([CH:9]([C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)[N:10]2[CH2:15][CH2:14][N:13]([CH2:16][C:17]3[CH:31]=[CH:30][C:20]4[N:21]([CH3:29])[C:22]([NH:24]C(=O)OC)=[N:23][C:19]=4[CH:18]=3)[CH2:12][CH2:11]2)[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.Cl>O>[C:32]1([CH:9]([C:3]2[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=2)[N:10]2[CH2:15][CH2:14][N:13]([CH2:16][C:17]3[CH:31]=[CH:30][C:20]4[N:21]([CH3:29])[C:22]([NH2:24])=[N:23][C:19]=4[CH:18]=3)[CH2:12][CH2:11]2)[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 86736742HCID 86736742, compound

Product 1

HCID 20298830HCID 20298830, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a stirred solution of 4 parts of sodium hydroxide in 50 parts of water are added 4.7 parts of methyl {5-[4-(diphenylmethyl)-1-piperazinylmethyl]-1-methyl-1H-benzimidazol-2-yl}carbamate. The whole is stirred and refluxed for 3.50 hours. The reaction mixture is cooled and allowed to stand overnight. It is acidified with a hydrochloric acid solution 10 N. The precipitated product is filtered off, washed with water and boiled in ethanol. After cooling, the product is filtered off, washed with ethanol and with 2,2'-oxybispropane and dried, yielding 2.5 parts of 5-[4-(diphenylmethyl)-1-piperazinylmethyl]-1-methyl-1H-benzimidazol-2-amine; mp. 267.5° C.

Workup

  1. temperaturerefluxed for 3.50 hours
  2. temperatureThe reaction mixture is cooled
  3. filtrationThe precipitated product is filtered off
  4. washwashed with water
  5. temperatureAfter cooling
  6. filtrationthe product is filtered off
  7. washwashed with ethanol and with 2,2'-oxybispropane
  8. customdried

Sources & evidence

ORD record
ord-568d8654948d4ef18a5b4d751c9c5ef8
Source dataset
uspto-grants-1981_01
Patent number
US04243806

Reaction notes

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