2-Bromoisovaleric acid → HCID 54166781, compound

HRID 1389347Notes

Reaction equation

HRID 1389347 reaction equation
Br[CH:2]([CH:6]([CH3:8])[CH3:7])[C:3]([OH:5])=[O:4].[CH2:9]1[O:18][C:17]2[CH:16]=[CH:15][C:13]([NH2:14])=[CH:12][C:11]=2[O:10]1>>[CH2:9]1[O:18][C:17]2[CH:16]=[CH:15][C:13]([NH:14][C@H:2]([C:3]([OH:5])=[O:4])[CH:6]([CH3:8])[CH3:7])=[CH:12][C:11]=2[O:10]1

Participants

3

Reactant 2

HCID 112682-Bromoisovaleric acidHCID 843101,3-Benzodioxol-5-amine

Product 1

HCID 54166781HCID 54166781, compound

Procedure

Following the procedure of Example 1, the m-phenoxybenzyl ester of α-bromoisovaleric acid is reacted with 3,4-methylenedioxyaniline (3equivalents) at about 75° for about 14 hours to yield the m-phenoxybenzyl ester of N-(3,4-methylenedioxyphenyl)valine, MS m/e 419 (M+, 13.2), 192 (100).

Sources & evidence

ORD record
ord-d5bd3d94e17945b49e210896e359d031
Source dataset
uspto-grants-1981_01
Patent number
US04243819

Reaction notes

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