2-Bromoisovaleric acid → HCID 54446014, compound

HRID 1389379Notes

Reaction equation

HRID 1389379 reaction equation
[F:1][C:2]([S:5][C:6]1[CH:11]=[CH:10][C:9]([NH2:12])=[CH:8][CH:7]=1)([F:4])[F:3].[Na].Br[CH:15]([CH:19]([CH3:21])[CH3:20])[C:16]([OH:18])=[O:17]>>[F:1][C:2]([F:4])([F:3])[S:5][C:6]1[CH:11]=[CH:10][C:9]([NH:12][C@H:15]([C:16]([OH:18])=[O:17])[CH:19]([CH3:21])[CH3:20])=[CH:8][CH:7]=1

Participants

4

Reactant 3

HCID 112682-Bromoisovaleric acidHCID 1230544-((Trifluoromethyl)thio)anilineHCID 5360545Sodium

Product 1

HCID 54446014HCID 54446014, compound

Procedure

Alternatively, using the procedure of Example 38, p-aminophenyl trifluoromethyl sulfide is reacted with the sodium salt of α-bromoisovaleric acid to yield N-(4-trifluoromethylthiophenyl)valine, which is esterified to yield the m-phenoxybenzyl ester of N-(4-trifluoromethylthiophenyl)valine.

Sources & evidence

ORD record
ord-ddce22ddfe05432ab2fa91529599ee5d
Source dataset
uspto-grants-1981_01
Patent number
US04243819

Reaction notes

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