2-Bromoisovaleric acid → HCID 54566757, compound

HRID 1389381Notes

Reaction equation

[F:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][C:8]=1[C:9]([F:12])([F:11])[F:10])[NH2:5].[Na].Br[CH:15]([CH:19]([CH3:21])[CH3:20])[C:16]([OH:18])=[O:17]>>[F:1][C:2]1[CH:3]=[C:4]([NH:5][C@H:15]([C:16]([OH:18])=[O:17])[CH:19]([CH3:21])[CH3:20])[CH:6]=[CH:7][C:8]=1[C:9]([F:10])([F:11])[F:12]

Participants

Reactant 3

HCID 112682-Bromoisovaleric acid

HCID 27359144-Amino-2-fluorobenzotrifluoride

HCID 5360545Sodium

Product 1

HCID 54566757HCID 54566757, compound

Procedure

Following the procedure of Example 38, 3-fluoro-4-trifluoromethylaniline is reacted with the sodium salt of α-bromoisovaleric acid to yield N-(3-fluoro-4-trifluoromethylphenyl)valine, which is esterifed to yield the m-phenoxybenzyl ester of N-(3-fluoro-4-trifluoromethylphenyl)valine.

Sources & evidence

ORD record: ord-aa569eb1bb3b4e2c812ed7f77f116c52
Source dataset: uspto-grants-1981_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04243819

Reaction notes

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