Hydrogen Bromide → HCID 12893592, compound

HRID 1389438Notes

Reaction equation

HRID 1389438 reaction equation
[BrH:1].C(OC([N:7]1[CH2:12][CH2:11][C:10]2[N:13]3[CH:18]=[C:17]([C:19]4[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=4)[N:16]=[C:14]3[S:15][C:9]=2[CH2:8]1)=O)C.Br>C(O)(=O)C>[BrH:1].[BrH:1].[C:19]1([C:17]2[N:16]=[C:14]3[N:13]([CH:18]=2)[C:10]2[CH2:11][CH2:12][NH:7][CH2:8][C:9]=2[S:15]3)[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1

Participants

4

Reactant 2

HCID 260Hydrogen Bromide2×HCID 12893590HCID 12893590, compound

Product 1

HCID 12893592HCID 12893592, compoundYield 186.2%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A mixture of 4.1 g of 7-ethoxycarbonyl-2-phenyl-5,6,7,8-tetrahydroimidazo[2',1':2,3]thiazolo[5,4-c]pyridine hydrobromide and 50 ml of a solution of hydrobromic acid in acetic acid (20% (w/w) hydrobromic acid) was heated on a boiled water bath for 2 hours. The precipitated crystals were filtered off and washed with a mixture of ethanol and n-hexane to give 3.9 g of 2-phenyl-5,6,7,8-tetrahydroimidazo[2',1':2,3]thiazolo[5,4-c]pyridine dihydrobromide, melting at 315°-316° C. with decomposition.

Workup

  1. temperaturewas heated on a boiled water bath for 2 hours
  2. filtrationThe precipitated crystals were filtered off
  3. washwashed with a mixture of ethanol and n-hexane

Sources & evidence

ORD record
ord-79d3b76532db4c8f9851bbc66a8bde90
Source dataset
uspto-grants-1981_01
Patent number
US04244952

Reaction notes

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