Hydrogen Bromide → HCID 12893598, compound

HRID 1389439Notes

Reaction equation

HRID 1389439 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[C:10]3[N:18]([CH:19]=2)[C:17]2[CH2:16][CH2:15][N:14](C(OCC)=O)[CH2:13][C:12]=2[S:11]3)=[CH:4][CH:3]=1.[BrH:25]>C(O)(=O)C>[BrH:25].[BrH:25].[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[C:10]3[N:18]([CH:19]=2)[C:17]2[CH2:16][CH2:15][NH:14][CH2:13][C:12]=2[S:11]3)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 260Hydrogen Bromide2×HCID 12893588HCID 12893588, compound

Product 1

HCID 12893598HCID 12893598, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A mixture of 9 g of the product of Example 5 and 100 ml of a solution of hydrobromic acid in acetic acid (20% (w/w) hydrobromic acid) was heated on a boiled water bath for one hour. The precipitated crystals were filtered off and washed with n-hexane to give 9.3 g of 2-(4-chlorophenyl)-5,6,7,8-tetrahydroimidazo[2',1':2,3]thiazolo[5,4-c]pyridine dihydrobromide, melting at 304°-307° C. with decomposition.

Workup

  1. temperaturewas heated on a boiled water bath for one hour
  2. filtrationThe precipitated crystals were filtered off
  3. washwashed with n-hexane

Sources & evidence

ORD record
ord-cefe177708bd49908b6b1820d59f62ac
Source dataset
uspto-grants-1981_01
Patent number
US04244952

Reaction notes

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