Carbon Dioxide → HCID 20296624, compound

Participants

Reaction Conditions

Reaction Steps

4.0 g. (0.02 mole) of phenylsulfonylacetic acid was dissolved in 15 ml. of dioxane followed by a solution of 2.0 g. (0.02 mole) of 4-hydroxypiperidine in 20 ml. of dioxane and 2 ml. of water. At 30° C. 3.5 g. (0.04 mole) of 37% aqueous formaldehyde was added rapidly and the reaction mixture agitated thoroughly. The temperature was gradually raised by means of an oil bath to 42° C. and carbon dioxide evolution was initiated. The mixture was maintained at approximately 42° C. for an additional 2 hours. The solvent was removed under reduced pressure and the product was obtained as a residue.

Provenance & Evidence