Carbon Dioxide → HCID 20296624, compound

HRID 1389462Notes

Reaction equation

HRID 1389462 reaction equation
[C:1]1([S:7]([CH2:10][C:11](O)=O)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH:14][CH:15]1[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]1.C=O.[C:23](=O)=O>O.O1CCOCC1>[C:1]1([S:7]([C:10](=[CH2:11])[CH2:23][N:18]2[CH2:19][CH2:20][CH:15]([OH:14])[CH2:16][CH2:17]2)(=[O:8])=[O:9])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

7

Reactant 4

HCID 280Carbon DioxideHCID 712FormaldehydeHCID 59543(phenylsulfonyl)acetic acidHCID 79341Piperidin-4-ol

Product 1

HCID 20296624HCID 20296624, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 312751,4-DioxaneSolvent2×

Conditions

Temperature
42 °C

Procedure

4.0 g. (0.02 mole) of phenylsulfonylacetic acid was dissolved in 15 ml. of dioxane followed by a solution of 2.0 g. (0.02 mole) of 4-hydroxypiperidine in 20 ml. of dioxane and 2 ml. of water. At 30° C. 3.5 g. (0.04 mole) of 37% aqueous formaldehyde was added rapidly and the reaction mixture agitated thoroughly. The temperature was gradually raised by means of an oil bath to 42° C. and carbon dioxide evolution was initiated. The mixture was maintained at approximately 42° C. for an additional 2 hours. The solvent was removed under reduced pressure and the product was obtained as a residue.

Workup

  1. customAt 30° C
  2. temperatureThe mixture was maintained at approximately 42° C. for an additional 2 hours
  3. customThe solvent was removed under reduced pressure
  4. customthe product was obtained as a residue

Sources & evidence

ORD record
ord-c27cbc0488434fc68ca6a7475223f3a2
Source dataset
uspto-grants-1981_01
Patent number
US04244963

Reaction notes

Loading…