Tetrahydrofuran → 1-[6-(4-Bromo-2-chloro-phenylamino)-7-fluoro-3H-benzoimidazol-5-yl]-2-(isopropoxy-dimethyl-silanyl)-ethanol
Reaction equation
[Br:10][c:11]1[cH:12][c:13]([Cl:30])[c:14]([NH:17][c:18]2[c:19]([CH:28]=[O:29])[cH:20][c:21]3[c:22]([n:23][cH:24][nH:25]3)[c:26]2[F:27])[cH:15][cH:16]1.[CH2:31]1[O:32][CH2:33][CH2:34][CH2:35]1.[Cl:1][CH2:2][Si:3]([O:4][CH:5]([CH3:6])[CH3:7])([CH3:8])[CH3:9]>>[CH2:2]([Si:3]([O:4][CH:5]([CH3:6])[CH3:7])([CH3:8])[CH3:9])[CH:28]([c:19]1[c:18]([NH:17][c:14]2[c:13]([Cl:30])[cH:12][c:11]([Br:10])[cH:16][cH:15]2)[c:26]([F:27])[c:22]2[c:21]([cH:20]1)[nH:25][cH:24][n:23]2)[OH:29]Participants
4
Sources & evidence
- ORD record
- ord-c07f4221d14b443d9694c373f0f756e0
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (9/10)
Reaction notes
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