Hydrochloric Acid → HCID 131712029, compound

HRID 1389480Notes

Reaction equation

HRID 1389480 reaction equation
[C:1]1([O:11][CH2:12][CH:13]([OH:26])[CH2:14][N:15]2[CH2:25][CH2:24][C:18]3([O:22][C:21](=[O:23])[NH:20][CH2:19]3)[CH2:17][CH2:16]2)[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.[ClH:27].C(OCC)C>CO>[ClH:27].[C:1]1([O:11][CH2:12][CH:13]([OH:26])[CH2:14][N:15]2[CH2:25][CH2:24][C:18]3([O:22][C:21](=[O:23])[NH:20][CH2:19]3)[CH2:17][CH2:16]2)[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 20296598HCID 20296598, compound

Product 1

HCID 131712029HCID 131712029, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

To a solution of 1 g 8-[3-(1-naphthyloxy)-2-hydroxypropyl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one in 5 ml methanol is added 10 ml 3% hydrochloric acid in methanol. Addition of 200 ml diethyl ether followed by filtration affords 8-[3-(1-naphthyloxy)-2-hydroxypropyl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one hydrochoride, mp 137°-140°.

Workup

  1. filtrationfollowed by filtration

Sources & evidence

ORD record
ord-92a1e3c51ee84be4a7d2655a67a14fec
Source dataset
uspto-grants-1981_01
Patent number
US04244961

Reaction notes

Loading…