Hydrogen Bromide → HCID 23460930, compound

HRID 1389486Notes

Reaction equation

HRID 1389486 reaction equation
[CH2:1]([C:3]1[N:4]([C:8]2[CH:13]=[CH:12][C:11]([O:14]C)=[CH:10][CH:9]=2)[CH:5]=[CH:6][N:7]=1)[CH3:2].[BrH:16]>C(O)(=O)C>[BrH:16].[CH2:1]([C:3]1[N:4]([C:8]2[CH:13]=[CH:12][C:11]([OH:14])=[CH:10][CH:9]=2)[CH:5]=[CH:6][N:7]=1)[CH3:2]

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 13019880HCID 13019880, compound

Product 1

HCID 23460930HCID 23460930, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A mixture of 5.2 parts of 2-ethyl-1-(4-methoxyphenyl)-1H-imidazole and 75 parts of hydrobromic acid solution 48% in glacial acetic acid is stirred and refluxed overnight. The solvent is evaporated and the residue is triturated in 2-propanone. The product is filtered off and dried, yielding 6.1 parts (100% ) of 4-(2-ethyl-1H-imidazol-1-yl)phenol monohydrobromide.

Workup

  1. temperaturerefluxed overnight
  2. customThe solvent is evaporated
  3. customthe residue is triturated in 2-propanone
  4. filtrationThe product is filtered off
  5. customdried

Sources & evidence

ORD record
ord-9d6db861f60a4580924666e2fe132e0b
Source dataset
uspto-grants-1981_01
Patent number
US04244964

Reaction notes

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