1-Butanol → HCID 178492027, compound

HRID 1389497Notes

Reaction equation

HRID 1389497 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([NH:9][NH:10][C:11](=[S:13])[NH2:12])=[CH:5][CH:4]=1.[C:14](O)(=O)C.C(=N)N.C(O)CCC.O(C(C)C)C(C)C>O>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([N:9]2[CH:14]=[N:12][C:11]([SH:13])=[N:10]2)=[CH:7][CH:8]=1

Participants

6

Reactant 4

HCID 2631-ButanolHCID 7914Diisopropyl EtherHCID 160693Formamidine acetateHCID 28261724-Methoxyphenylthiosemicarbazide

Product 1

HCID 178492027HCID 178492027, compoundYield 73%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 10 parts of 2-(4-methoxyphenyl)hydrazinecarbothioamide, 10.6 parts of methanimidamide acetate and 80 parts of 1-butanol is stirred and refluxed for 1 hour. After cooling, water and 2,2'-oxybispropane are added, whereupon the product is precipitated. It is filtered off and dried, yielding 7.6 parts (73%) of 1-(4-methoxyphenyl)-1H-1,2,4-triazole-3-thiol.

Workup

  1. temperaturerefluxed for 1 hour
  2. temperatureAfter cooling
  3. customis precipitated
  4. filtrationIt is filtered off
  5. customdried

Sources & evidence

ORD record
ord-b2b77d6c3f8d47398e8aafc42670caad
Source dataset
uspto-grants-1981_01
Patent number
US04244964

Reaction notes

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