Dichloromethane → 1-(4-(Azetidin-3-yloxy)-3-methylbenzyl)-4-methylpiperazine

HRID 138950Notes

Reaction equation

HRID 138950 reaction equation
[CH3:1][c:2]1[c:3]([O:4][CH:5]2[CH2:6][N:7]([C:9]([O:10][C:11]([CH3:12])([CH3:13])[CH3:14])=[O:15])[CH2:8]2)[cH:16][cH:17][c:18]([CH2:20][N:21]2[CH2:22][CH2:23][N:24]([CH3:27])[CH2:25][CH2:26]2)[cH:19]1.[Cl:35][CH2:36][Cl:37].[F:28][C:29]([F:30])([F:31])[C:32]([OH:33])=[O:34]>>[CH3:1][c:2]1[c:3]([O:4][CH:5]2[CH2:6][NH:7][CH2:8]2)[cH:16][cH:17][c:18]([CH2:20][N:21]2[CH2:22][CH2:23][N:24]([CH3:27])[CH2:25][CH2:26]2)[cH:19]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 58043145tert-Butyl 3-(2-methyl-4-((4-methylpiperazin-1-yl)methyl)phenoxy)azetidine-1-carboxylate

Product 1

HCID 670165511-(4-(Azetidin-3-yloxy)-3-methylbenzyl)-4-methylpiperazine

Sources & evidence

ORD record
ord-c7cbfef8f2b9451ab89f4ae07c851e59
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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