Hydrochloric Acid → 7-(3-((2-(3,5-Dihydroxyphenyl)-2-oxoethyl)(phenylmethyl)amino)propyl)-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione monohydrochloride

HRID 1389543Notes

Reaction equation

HRID 1389543 reaction equation
[ClH:1].C([O:5][C:6]1[CH:7]=[C:8]([C:16](=[O:42])[CH2:17][N:18]([CH2:35][C:36]2[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=2)[CH2:19][CH2:20][CH2:21][N:22]2[C:31]3[C:30](=[O:32])[N:28]([CH3:29])[C:27](=[O:33])[N:26]([CH3:34])[C:25]=3[N:24]=[CH:23]2)[CH:9]=[C:10]([O:12]C(=O)C)[CH:11]=1)(=O)C.Cl>CO>[ClH:1].[OH:5][C:6]1[CH:7]=[C:8]([C:16](=[O:42])[CH2:17][N:18]([CH2:35][C:36]2[CH:37]=[CH:38][CH:39]=[CH:40][CH:41]=2)[CH2:19][CH2:20][CH2:21][N:22]2[C:31]3[C:30](=[O:32])[N:28]([CH3:29])[C:27](=[O:33])[N:26]([CH3:34])[C:25]=3[N:24]=[CH:23]2)[CH:9]=[C:10]([OH:12])[CH:11]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 7057790873749-29-8

Product 1

HCID 30161707-(3-((2-(3,5-Dihydroxyphenyl)-2-oxoethyl)(phenylmethyl)amino)propyl)-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione monohydrochloride

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The wet product of step (b) containing 12.8 kg of diacetyl compound was added to 25.6 liters of methanol and 12.8 liters of 10% hydrochloric acid. The mixture was boiled for one hour at reflux, treated with some activated carbon and kieselguhr, filtered and allowed to cool. On the next day it was centrifuged, washed with water and dried.

Workup

  1. temperatureat reflux
  2. additiontreated with some activated carbon and kieselguhr
  3. filtrationfiltered
  4. temperatureto cool
  5. washwashed with water
  6. customdried

Sources & evidence

ORD record
ord-ca9c4952472249b58b82803b2f3ae509
Source dataset
uspto-grants-1981_01
Patent number
US04245093

Reaction notes

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