Hydrochloric Acid → Pyridine, 2,3,5-trichloro-

HRID 1389545Notes

Reaction equation

HRID 1389545 reaction equation
[Cl:1][CH:2]([CH2:5][C:6]([Cl:10])(Cl)[CH:7]=O)[C:3]#[N:4].[ClH:11]>>[Cl:11][C:7]1[C:6]([Cl:10])=[CH:5][C:2]([Cl:1])=[CH:3][N:4]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 129361852,4,4-Trichloro-5-oxopentanenitrile2×

Product 1

HCID 27666Pyridine, 2,3,5-trichloro-

Procedure

The 2,4,4-trichloro-4-formyl-butyronitrile (17.3 g) obtained according to (a) is heated, as a weak stream of hydrogen chloride is being introduced, at 80°-85° C. for 24 hours. The entire reaction mixture is subsequently distilled with steam. The yield is 10.0 g (72% of theory) of 2,3,5-trichloropyridine in the form of white crystals, m.p. 49°-50° C.

Workup

  1. additionis being introduced, at 80°-85° C. for 24 hours
  2. customThe entire reaction mixture
  3. distillationis subsequently distilled with steam

Sources & evidence

ORD record
ord-508772a2e1d84a919886ccbd52e62fa2
Source dataset
uspto-grants-1981_01
Patent number
US04245098

Reaction notes

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