Hydrochloric Acid → HCID 20297011, compound

HRID 1389563Notes

Reaction equation

HRID 1389563 reaction equation
[C:1]([C:4]1[CH:9]=[C:8]([C:10]([CH3:13])([CH3:12])[CH3:11])[CH:7]=[C:6]([CH2:14][NH:15]C(=O)C[Cl:18])[C:5]=1[OH:20])(=[O:3])[CH3:2].Cl>C(O)C>[ClH:18].[C:1]([C:4]1[CH:9]=[C:8]([C:10]([CH3:11])([CH3:13])[CH3:12])[CH:7]=[C:6]([CH2:14][NH2:15])[C:5]=1[OH:20])(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 202969572-Acetyl-4-tert-butyl-6-(N-chloroacetylaminomethyl)phenol

Product 1

HCID 20297011HCID 20297011, compoundYield 92.3%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To 1.49 g of 2-acetyl-4-tert-butyl-6-(N-chloroacetylaminomethyl)phenol (prepared in Example 1) dissolved in 10 ml of ethanol were added 4.0 ml of conc. hydrochloric acid and heated at reflux for 20 hous. The reaction mixture was concentrated at reduced pressure and the residue was recrystallized from a mixed solvent of methanol and diethyl ether to give 1.19 g of the title compound having the following physical properties as white needles.

Workup

  1. temperatureheated
  2. temperatureat reflux for 20 hous
  3. concentrationThe reaction mixture was concentrated at reduced pressure
  4. customthe residue was recrystallized from a mixed solvent of methanol and diethyl ether

Sources & evidence

ORD record
ord-eb9e2f91c60448a7b05310d8f4c28757
Source dataset
uspto-grants-1981_01
Patent number
US04245099

Reaction notes

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