反应详情

To 1.49 g of 2-acetyl-4-tert-butyl-6-(N-chloroacetylaminomethyl)phenol (prepared in Example 1) dissolved in 10 ml of ethanol were added 4.0 ml of conc. hydrochloric acid and heated at reflux for 20 hous. The reaction mixture was concentrated at reduced pressure and the residue was recrystallized from a mixed solvent of methanol and diethyl ether to give 1.19 g of the title compound having the following physical properties as white needles.

1. temperatureheated
2. temperatureat reflux for 20 hous
3. concentrationThe reaction mixture was concentrated at reduced pressure
4. customthe residue was recrystallized from a mixed solvent of methanol and diethyl ether