Hydrochloric Acid → HCID 20296962, compound

HRID 1389567Notes

Reaction equation

HRID 1389567 reaction equation
[C:1]([C:5]1[C:14]2[CH2:13][CH2:12][CH2:11][CH2:10][C:9]=2[CH:8]=[C:7]([CH2:15][NH:16]C(=O)C)[C:6]=1[OH:20])(=[O:4])[CH2:2][CH3:3].[ClH:21]>CO>[ClH:21].[C:1]([C:5]1[C:14]2[CH2:13][CH2:12][CH2:11][CH2:10][C:9]=2[CH:8]=[C:7]([CH2:15][NH2:16])[C:6]=1[OH:20])(=[O:4])[CH2:2][CH3:3]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 20297066HCID 20297066, compound

Product 1

HCID 20296962HCID 20296962, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To 400 mg of the compound obtained in Example 4 (a) above were added 2 ml of methanol and 1 ml of concentrated hydrochloric acid followed by refluxing for 15 hours. The mixture was concentrated, and the residue was washed with diethyl ether and dissolved in methanol. Activated carbon was added to the solution which was then filtered. Diethyl ether was added to the filtrate and the precipitated crystals were filtered to obtain 160 mg of the title compound having the following physical properties.

Workup

  1. temperatureby refluxing for 15 hours
  2. concentrationThe mixture was concentrated
  3. washthe residue was washed with diethyl ether
  4. dissolutiondissolved in methanol
  5. additionActivated carbon was added to the solution which
  6. filtrationwas then filtered
  7. additionDiethyl ether was added to the filtrate
  8. filtrationthe precipitated crystals were filtered

Sources & evidence

ORD record
ord-e42e27bcb33c4aa8ac709b4e4cf7c552
Source dataset
uspto-grants-1981_01
Patent number
US04245099

Reaction notes

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