反应详情

A suspension of 45.3 g. of 1-benzyloxy-2-[(2,6-dichlorophenyl)imino]-imidazolidine in 450 ml. of 48% strength hydrobromic acid is warmed to 80° for 4 hours. The resulting solution is poured onto ice and extracted with ether. The aqueous phase is evaporated in vacuo. The residue is distilled azeotropically five times with a mixture of ethanol/ethyl acetate. 2-[(2,6-dichlorophenyl)imino]-1-hydroxyimidazolidine hydrobromide is obtained by crystallization from a mixture of ethanol/ethyl acetate/ether. An analytically pure sample, m.p. 233°-234°, is obtained by recrystallization from methanol/acetonitrile.

1. additionA suspension of 45.3 g
2. additionThe resulting solution is poured onto ice
3. extractionextracted with ether
4. customThe aqueous phase is evaporated in vacuo
5. distillationThe residue is distilled azeotropically five times
6. additionwith a mixture of ethanol/ethyl acetate