Hydrochloric Acid → HCID 178525502, compound

HRID 1389580Notes

Reaction equation

HRID 1389580 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[N:9]=[C:10]1[NH:14][CH2:13][CH2:12][N:11]1[O:15][CH2:16][CH2:17][CH2:18][C:19]([O:21]CC)=[O:20].Cl.C([O-])(=O)C.[Na+]>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[N:9]=[C:10]1[NH:14][CH2:13][CH2:12][N:11]1[O:15][CH2:16][CH2:17][CH2:18][C:19]([OH:21])=[O:20]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 517045Sodium AcetateHCID 178471737HCID 178471737, compound

Product 1

HCID 178525502HCID 178525502, compound

Procedure

38.80 g. of ethyl 4-{[2-[(2,6-dichlorophenyl)imino]-1-imidazolidinyl]oxy}butyrate and 50 ml. of 25% strength hydrochloric acid are warmed to 125° for 45 minutes. The cooled solution is adjusted to pH 5 with sodium acetate and extracted with chloroform. The organic extracts are dried over magnesium sulfate and evaporated in vacuo. The residue is recrystallized from chloroform/ether, whereupon 4-{[2-[(2,6-dichlorophenyl)imino]-1-imidazolidinyl]oxy}butyric acid, m.p. 115°, is obtained.

Workup

  1. extractionextracted with chloroform
  2. dry with materialThe organic extracts are dried over magnesium sulfate
  3. customevaporated in vacuo
  4. customThe residue is recrystallized from chloroform/ether, whereupon 4-{[2-[(2,6-dichlorophenyl)imino]-1-imidazolidinyl]oxy}butyric acid, m.p. 115°
  5. customis obtained

Sources & evidence

ORD record
ord-dfb4ebfd80344a2fbd8df76daff23e87
Source dataset
uspto-grants-1981_01
Patent number
US04244957

Reaction notes

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