Sulfuric Acid → HCID 178526276, compound

HRID 1389583Notes

Reaction equation

HRID 1389583 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[N:9]=[C:10]1[NH:14][CH2:13][CH2:12][NH:11]1.S(=O)(=O)(O)[OH:16].S(OOS([O-])(=O)=O)([O-])(=O)=O.[K+].[K+].[OH-].[Na+]>O>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[N:9]=[C:10]1[NH:11][CH2:12][CH2:13][N:14]1[OH:16]

Participants

6

Reactant 4

HCID 1118Sulfuric AcidHCID 14798Sodium HydroxideHCID 24412Potassium PersulfateHCID 178478105HCID 178478105, compound

Product 1

HCID 178526276HCID 178526276, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

2.30 g. of 2-[(2,6-dichlorophenyl)imino]-imidazolidine are dissolved in 10 ml. of concentrated sulfuric acid, and 2.97 g. of potassium persulfate are added in portions at room temperature. The temperature is kept below 50° with a cooling bath. The dark solution is diluted with water and rendered highly alkaline with concentrated caustic soda solution. The unreacted starting material is extracted with ether. The aqueous solution is adjusted to pH 7 with glacial acetic acid and then with sodium bicarbonate. The residue is filtered off from the solution and a potassium carbonate solution is added to the filtrate up to pH 10.5. The product which has precipitated is extracted with ethyl acetate and recrystallized twice from acetonitrile, whereupon 2-[(2,6-dichlorophenyl)-imino]-1-hydroxyimidazolidine of melting point 215°, which is identical to the product obtained in Example 3, is obtained.

Workup

  1. customThe temperature is kept below 50° with a cooling bath
  2. extractionis extracted with ether
  3. filtrationThe residue is filtered off from the solution
  4. additiona potassium carbonate solution is added to the filtrate up to pH 10.5
  5. customThe product which has precipitated
  6. extractionis extracted with ethyl acetate
  7. customrecrystallized twice from acetonitrile, whereupon 2-[(2,6-dichlorophenyl)-imino]-1-hydroxyimidazolidine of melting point 215°, which
  8. customis obtained

Sources & evidence

ORD record
ord-6bb1523f66d340ae9f6d0287503dcdd7
Source dataset
uspto-grants-1981_01
Patent number
US04244957

Reaction notes

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