Hydroxyamine hydrochloride → HCID 86737438, compound

HRID 1389670Notes

Reaction equation

HRID 1389670 reaction equation
O=[C:2]([CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH3:29])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][NH:8][C:9]1[CH:19]=[CH:18][C:12]([C:13]([O:15][CH2:16][CH3:17])=[O:14])=[CH:11][CH:10]=1.Cl.[NH2:31][OH:32].C([O-])(=O)C.[Na+]>C(O)C>[N:31](=[C:2]([CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH3:29])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][NH:8][C:9]1[CH:19]=[CH:18][C:12]([C:13]([O:15][CH2:16][CH3:17])=[O:14])=[CH:11][CH:10]=1)[OH:32]

Participants

5

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 517045Sodium AcetateHCID 20482520HCID 20482520, compound

Product 1

HCID 86737438HCID 86737438, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 1.0 g. of ethyl 4-(6-oxohexadecylamino)benzoate, 207 mg. of hydroxylamine hydrochloride, 244 mg. of sodium acetate and 20 ml. of 95% ethanol is stirred under reflux for 3 hours and filtered. The filtrate is evaporated and a methylene chloride solution of the residue is washed with water, dried over magnesium sulfate, and evaporated to yield ethyl 4-(6-oximinohexadecylamino)benzoate as a white solid.

Workup

  1. additionA mixture of 1.0 g
  2. temperatureunder reflux for 3 hours
  3. filtrationfiltered
  4. customThe filtrate is evaporated
  5. washa methylene chloride solution of the residue is washed with water
  6. dry with materialdried over magnesium sulfate
  7. customevaporated

Sources & evidence

ORD record
ord-9765aed8ef774e4db71e32057c160d9c
Source dataset
uspto-grants-1981_01
Patent number
US04245097

Reaction notes

Loading…