Hydrogen Bromide → HCID 20295355, compound

HRID 1389765Notes

Reaction equation

HRID 1389765 reaction equation
C([N:8]1[CH:14]=[CH:13][CH:12]=[C:11]([O:15][CH2:16][CH2:17][OH:18])[CH:10]=[CH:9]1)C1C=CC=CC=1.[BrH:19]>O.[Pd]>[BrH:19].[OH:18][CH2:17][CH2:16][O:15][C:11]1[CH:10]=[CH:9][NH:8][CH:14]=[CH:13][CH:12]=1

Participants

5

Reactant 2

HCID 260Hydrogen BromideHCID 20295344HCID 20295344, compound

Product 1

HCID 20295355HCID 20295355, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 962WaterSolvent

Procedure

To a suspension of (B) (7.5 g) in water (20 ml), 1 N hydrobromic acid (30 ml) was added. The clear solution was hydrogenated over 10% palladium on carbon catalyst (4 g). After 3 hours the consumption of hydrogen ceased; the catalyst was filtered off, and the filtrate taken to dryness in vacuo. The residue was distilled twice with chloroform to give (C) as a viscous oil.

Workup

  1. additionwas added
  2. customAfter 3 hours the consumption of hydrogen
  3. filtrationthe catalyst was filtered off
  4. distillationThe residue was distilled twice with chloroform

Sources & evidence

ORD record
ord-74d5ad633cf643d3a1ab7b510d4f8ff8
Source dataset
uspto-grants-1981_01
Patent number
US04246262

Reaction notes

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