反应详情

4.0 g of 3,4-epoxy-1-(β,β,β-trichloroethoxycarbonyl)-pyrrolidine are dissolved in 15 ml of dioxane, and the solution is treated with 50 ml of 6 N hydrochloric acid. The slightly exothermic reaction is kept at room temperature by means of a water bath, and the reaction mixture is stirred for 15 hours, then diluted with water and extracted 3 times with 100 ml of methylene chloride. The organic phase is washed with 0.1 N sodium hydroxide solution and then with aqueous sodium chloride solution, dried over sodium sulphate and then evaporated to dryness, first under a water pump vacuum and then under a high vacuum, 3-hydroxy-4-chloro-1-(β,β,β-trichloroethoxycarbonyl)-pyrrolidine being obtained as a slightly yellow oil.

1. customThe slightly exothermic reaction
2. customis kept at room temperature by means of a water bath
3. extractionextracted 3 times with 100 ml of methylene chloride
4. washThe organic phase is washed with 0.1 N sodium hydroxide solution
5. dry with materialwith aqueous sodium chloride solution, dried over sodium sulphate
6. customevaporated to dryness, first under a water pump vacuum