Hydrochloric Acid → 6-Chloro-2-naphthyl 4-piperidyl ketone hydrochloride

HRID 1389862Notes

Reaction equation

HRID 1389862 reaction equation
[NH:1]1[CH2:6][CH2:5][CH:4]([C:7]([C:9]2[CH:18]=[CH:17][C:16]3[C:11](=[CH:12][CH:13]=[C:14]([Cl:19])[CH:15]=3)[CH:10]=2)=[O:8])[CH2:3][CH2:2]1.Cl>CCOCC>[ClH:19].[NH:1]1[CH2:6][CH2:5][CH:4]([C:7]([C:9]2[CH:18]=[CH:17][C:16]3[C:11](=[CH:12][CH:13]=[C:14]([Cl:19])[CH:15]=3)[CH:10]=2)=[O:8])[CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 543200266-Chloro-2-naphthyl 4-piperidyl ketone

Product 1

HCID 705701616-Chloro-2-naphthyl 4-piperidyl ketone hydrochloride

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

The 6-chloro-2-naphthyl 4-piperidyl ketone prepared in Example 3 is reacted with an excess of HCl dissolved in ether and recrystallized from absolute ethanol to yield 6-chloro-2-naphthyl 4-piperidyl ketone hydrochloride. M.P. 259°-64°.

Workup

  1. customrecrystallized from absolute ethanol

Sources & evidence

ORD record
ord-cbe671ccea0b4bed82e8d801e59c6f55
Source dataset
uspto-grants-1981_01
Patent number
US04246268

Reaction notes

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