3-[4-(8-Methyl-1-naphthoyl)-1-piperidyl]-1-(4-fluorophenyl)-1-propanone → alpha-(4-Fluorophenyl)-4-[(8-methyl-1-naphthyl)hydroxymethyl]-1-piperidinepropanol

HRID 1389884Notes

Reaction equation

HRID 1389884 reaction equation
[CH3:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[C:10]([C:12]([CH:14]1[CH2:19][CH2:18][N:17]([CH2:20][CH2:21][C:22]([C:24]3[CH:29]=[CH:28][C:27]([F:30])=[CH:26][CH:25]=3)=[O:23])[CH2:16][CH2:15]1)=[O:13])=[CH:9][CH:8]=[CH:7]2.ClC1C=C2C(=CC=1)C=C(C(C1CCN(CCCC(C3C=CC(F)=CC=3)=O)CC1)=O)C=C2>>[F:30][C:27]1[CH:28]=[CH:29][C:24]([CH:22]([OH:23])[CH2:21][CH2:20][N:17]2[CH2:16][CH2:15][CH:14]([CH:12]([C:10]3[C:11]4[C:6](=[CH:5][CH:4]=[CH:3][C:2]=4[CH3:1])[CH:7]=[CH:8][CH:9]=3)[OH:13])[CH2:19][CH2:18]2)=[CH:25][CH:26]=1

Participants

3

Reactant 2

HCID 202955593-[4-(8-Methyl-1-naphthoyl)-1-piperidyl]-1-(4-fluorophenyl)-1-propanoneHCID 202956124-[4-(6-Chloro-2-naphthoyl)-1-piperidyl]-1-(4-fluorophenyl)-1-butanone

Product 1

HCID 20295568alpha-(4-Fluorophenyl)-4-[(8-methyl-1-naphthyl)hydroxymethyl]-1-piperidinepropanol

Procedure

When in the procedure of Example 39, 3-[4-(8-methyl-1-naphthoyl)-1-piperidyl]-1-(4-fluorophenyl)-1-propanone is substituted for 4-[4-(6-chloro-2-naphthoyl)-1-piperidyl]-1-(4-fluorophenyl)-1-butanone, α-(4-fluorophenyl)-4-[(8-methyl-1-naphthyl)hydroxymethyl]-1-piperidinepropanol is obtained.

Sources & evidence

ORD record
ord-05690a0840d2476c95b46ce2f98a997e
Source dataset
uspto-grants-1981_01
Patent number
US04246268

Reaction notes

Loading…