HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-[4-(8-Methyl-1-naphthoyl)-1-piperidyl]-1-(4-fluorophenyl)-1-propanone → alpha-(4-Fluorophenyl)-4-[(8-methyl-1-naphthyl)hydroxymethyl]-1-piperidinepropanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-[4-(8-Methyl-1-naphthoyl)-1-piperidyl]-1-(4-fluorophenyl)-1-propanone | HCID 20295559 | — |
| Reactant | 4-[4-(6-Chloro-2-naphthoyl)-1-piperidyl]-1-(4-fluorophenyl)-1-butanone | HCID 20295612 | — |
| Product | alpha-(4-Fluorophenyl)-4-[(8-methyl-1-naphthyl)hydroxymethyl]-1-piperidinepropanol | HCID 20295568 | — |
Reaction Steps
When in the procedure of Example 39, 3-[4-(8-methyl-1-naphthoyl)-1-piperidyl]-1-(4-fluorophenyl)-1-propanone is substituted for 4-[4-(6-chloro-2-naphthoyl)-1-piperidyl]-1-(4-fluorophenyl)-1-butanone, α-(4-fluorophenyl)-4-[(8-methyl-1-naphthyl)hydroxymethyl]-1-piperidinepropanol is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04246268 |
| Source dataset | uspto-grants-1981_01 |
| ORD ID | ord-05690a0840d2476c95b46ce2f98a997e |
| Source note | uspto-grants-1981_01 |