Tetrahydrofuran → 1-(2-chlorophenyl)-3-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)urea

HRID 138991Notes

Reaction equation

HRID 138991 reaction equation
[Cl:21][c:22]1[c:23]([N:28]=[C:29]=[O:30])[cH:24][cH:25][cH:26][cH:27]1.[NH2:1][CH:2]1[C:3](=[O:20])[N:4]([CH3:19])[c:5]2[c:6]([cH:15][cH:16][cH:17][cH:18]2)[C:7]([c:9]2[cH:10][cH:11][cH:12][cH:13][cH:14]2)=[N:8]1.[O:31]1[CH2:32][CH2:33][CH2:34][CH2:35]1>>[NH:1]([CH:2]1[C:3](=[O:20])[N:4]([CH3:19])[c:5]2[c:6]([cH:15][cH:16][cH:17][cH:18]2)[C:7]([c:9]2[cH:10][cH:11][cH:12][cH:13][cH:14]2)=[N:8]1)[C:29]([NH:28][c:23]1[c:22]([Cl:21])[cH:27][cH:26][cH:25][cH:24]1)=[O:30]

Participants

4

Reactant 3

HCID 8028TetrahydrofuranHCID 76833Chlorophenyl isocyanateHCID 27296813-Amino-1-methyl-5-phenyl-1H-benzo[E][1,4]diazepin-2(3H)-one

Product 1

HCID 156147821-(2-chlorophenyl)-3-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)urea

Sources & evidence

ORD record
ord-1d446a4e9f1342ddb65bb4b290a2c1b3
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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