Hydrochloric Acid → HCID 70537008, compound

HRID 1389943Notes

Reaction equation

HRID 1389943 reaction equation
Cl.[Cl:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([Cl:9])[C:4]=1[CH:10]([C:22]([OH:24])=[O:23])[NH:11][C:12]1[CH:21]=[CH:20][C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[CH:13]=1.[CH3:25]O>>[CH3:25][N:11]([C:12]1[CH:21]=[CH:20][C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[CH:13]=1)[CH:10]([C:4]1[C:3]([Cl:2])=[CH:8][CH:7]=[CH:6][C:5]=1[Cl:9])[C:22]([OH:24])=[O:23]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 20295984HCID 20295984, compound

Product 1

HCID 70537008HCID 70537008, compound

Procedure

Gaseous hydrogen chloride is introduced for 11 hours through a stirred and refluxing solution of 17.3 parts of (±)-2-(2,6-dichlorophenyl)-N-(2-naphthyl)glycine in 96 parts of methanol. The reaction mixture is allowed to cool overnight to room temperature. The precipitated product is filtered off and crystallized from methanol, yielding 6.4 parts of (±)-methyl 2-(2,6-dichlorophenyl)-N-(2-naphthyl) glycine; mp. 143.5° C.

Workup

  1. temperatureto cool overnight to room temperature
  2. filtrationThe precipitated product is filtered off
  3. customcrystallized from methanol

Sources & evidence

ORD record
ord-612ae22411d04b7fa24873efe6323d64
Source dataset
uspto-grants-1981_01
Patent number
US04246429

Reaction notes

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