反应详情

Gaseous hydrogen chloride is introduced for 11 hours through a stirred and refluxing solution of 17.3 parts of (±)-2-(2,6-dichlorophenyl)-N-(2-naphthyl)glycine in 96 parts of methanol. The reaction mixture is allowed to cool overnight to room temperature. The precipitated product is filtered off and crystallized from methanol, yielding 6.4 parts of (±)-methyl 2-(2,6-dichlorophenyl)-N-(2-naphthyl) glycine; mp. 143.5° C.

1. temperatureto cool overnight to room temperature
2. filtrationThe precipitated product is filtered off
3. customcrystallized from methanol