Sodium Hydroxide → HCID 23686191, compound

HRID 1389946Notes

Reaction equation

HRID 1389946 reaction equation
[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][CH:5]=[C:4]([Cl:9])[C:3]=1[CH:10]([NH:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[CH3:21])[C:11]([OH:13])=[O:12].[OH-].[Na+:23]>O>[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][CH:5]=[C:4]([Cl:9])[C:3]=1[CH:10]([NH:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[CH3:21])[C:11]([O-:13])=[O:12].[Na+:23]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 3018555(2-Methylanilino)(2,3,6-trichlorophenyl)acetic acid

Product 1

HCID 23686191HCID 23686191, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

A mixture of 8.62 parts of 2,3,6-trichloro-α-[(2-methylphenyl)amino]benzeneacetic acid, 25 parts of a sodium hydroxide solution 1 M in water and 100 parts of distilled water is stirred for 30 minutes at room temperature. The resulting solution is evaporated to dry, methylbenzene is added and evaporation is continued. The residue is suspended in 2,2'-oxybispropane. The product is filtered off and crystallized from acetonitrile, yielding 7 parts of sodium 2,3,6-trichloro-α-[(2-methylphenyl)amino]benzeneacetate; mp. 203.1° C.

Workup

  1. customThe resulting solution is evaporated
  2. customto dry
  3. additionmethylbenzene is added
  4. customevaporation
  5. filtrationThe product is filtered off
  6. customcrystallized from acetonitrile

Sources & evidence

ORD record
ord-c64219b1ab7e410b805f7530a49b7e5a
Source dataset
uspto-grants-1981_01
Patent number
US04246429

Reaction notes

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