Hydrochloric Acid → HCID 12902871, compound

HRID 1389988Notes

Reaction equation

HRID 1389988 reaction equation
[CH3:1][C:2]1[C:6]2[CH:7]=[C:8]([C:11]3[CH:16]=[CH:15][C:14]([CH2:17][C:18]([O:20]CC)=[O:19])=[CH:13][CH:12]=3)[CH:9]=[CH:10][C:5]=2[O:4][C:3]=1[N+:23]([O-:25])=[O:24].Cl>C(O)(=O)C>[CH3:1][C:2]1[C:6]2[CH:7]=[C:8]([C:11]3[CH:12]=[CH:13][C:14]([CH2:17][C:18]([OH:20])=[O:19])=[CH:15][CH:16]=3)[CH:9]=[CH:10][C:5]=2[O:4][C:3]=1[N+:23]([O-:25])=[O:24]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 23455900HCID 23455900, compound

Product 1

HCID 12902871HCID 12902871, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution of 1.5 g. of the product of step C in 25 ml. of acetic acid and 10 ml. of 6 N hydrochloric acid is heated at its reflux temperature for 45 minutes then poured into ice water. The precipitate is collected and recrystallized from an ethanol-N,N-dimethylformamide mixture to provide 4-(3-methyl-2-nitrobenzofuran-5-yl)phenylacetic acid, m.p. 229°-230° C.

Workup

  1. temperaturereflux temperature for 45 minutes
  2. customThe precipitate is collected
  3. customrecrystallized from an ethanol-N,N-dimethylformamide mixture

Sources & evidence

ORD record
ord-fe500f9afff24dafa89ce57aa853864d
Source dataset
uspto-grants-1981_01
Patent number
US04247469

Reaction notes

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