HCID 178464038, compound → HCID 178464039, compound

HRID 1390020Notes

Reaction equation

HRID 1390020 reaction equation
[CH2:1]([N:3]([CH2:18][CH3:19])[CH2:4][CH2:5][N:6]1[C:10]2[N:11]=[C:12]([O:15]C)[CH:13]=[CH:14][C:9]=2[N:8]=[C:7]1[OH:17])[CH3:2]>Br>[CH2:18]([N:3]([CH2:1][CH3:2])[CH2:4][CH2:5][N:6]1[C:10]2[N:11]=[C:12]([OH:15])[CH:13]=[CH:14][C:9]=2[N:8]=[C:7]1[OH:17])[CH3:19]

Participants

3

Reactant 1

HCID 178464038HCID 178464038, compound

Product 1

HCID 178464039HCID 178464039, compound

Reagents, catalysts & solvents 1

HCID 260Hydrogen BromideSolvent

Procedure

10 grams of 1-(2-diethylaminoethyl)-2-hydroxy-6-methoxy-7-aza-benzimidazole were boiled for 5 hours at reflux in 100 ml of 48% hydrobromic acid and the solution evaporated in a vacuum. The residue was stirred with isopropanol, filtered with suction and then recrystallized twice from ethanol under the addition of activated carbon.

Workup

  1. customthe solution evaporated in a vacuum
  2. filtrationfiltered with suction
  3. customrecrystallized twice from ethanol under the addition of activated carbon

Sources & evidence

ORD record
ord-01807b68e8ba478e9e6ac14a0a8b0d1a
Source dataset
uspto-grants-1981_01
Patent number
US04247556

Reaction notes

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