HCID 178474867, compound → HCID 178511322, compound

HRID 1390021Notes

Reaction equation

HRID 1390021 reaction equation
C([NH:4][CH2:5][CH2:6][N:7]1[C:11]2[N:12]=[C:13]([Cl:16])[CH:14]=[CH:15][C:10]=2[N:9]=[C:8]1[OH:17])(=O)C>Cl>[NH2:4][CH2:5][CH2:6][N:7]1[C:11]2[N:12]=[C:13]([Cl:16])[CH:14]=[CH:15][C:10]=2[N:9]=[C:8]1[OH:17]

Participants

3

Reactant 1

HCID 178474867HCID 178474867, compound

Product 1

HCID 178511322HCID 178511322, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

11 grams of 1-(2-acetylaminoethyl)-2-hydroxy-6-chloro-7-aza-benzimidazole were stirred for 4 hours with 40 ml of concentrated hydrochloric acid at 80° C. and then allowed to stand overnight at 0° C., the substance crystallized out was recrystallized from methanol. Yield: 5 grams; M.P. of the hydrochloride 310°-312° C.

Workup

  1. customthe substance crystallized out
  2. customwas recrystallized from methanol
  3. customM.P. of the hydrochloride 310°-312° C.

Sources & evidence

ORD record
ord-464399ea63b7494abab0817407294486
Source dataset
uspto-grants-1981_01
Patent number
US04247556

Reaction notes

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